Publications

High-throughput identification of gut microbiome-dependent metabolites, Nature Protocols (in press)

Han S^, Guiberson ER, Li Y, Sonnenburg JL^

^ co-corresponding authors

Metabolomic Applications in Gut Microbiota-Host Interactions in Human Diseases, Gastroenterology Clinics of North America (2024) Review

Li Y, Han S

Impact of 7-day homogenous diet on interpersonal variation in human gut microbiomes and metabolomes, Cell Host Microbe (2022)

Guthrie L, Spencer SP, Perelman D, Van Treuren W, Han S, Yu FB, Sonnenburg ED, Fischbach MA, Meyer TW, Sonnenburg JL

A metabolomics pipeline for the mechanistic interrogation of the gut microbiome, Nature (2021)

Han S*, Van Treuren W*, Fischer CR, Merrill BD, DeFelice BC, Sanchez JM, Higginbottom SK, Guthrie L, Fall LA, Dodd D, Fischbach MA, Sonnenburg JL

Constructed a microbiome-focused mass-spectrometry reference library and analytical pipeline (Python) to identify 800+ metabolites in diverse sample types
Discovered novel metabolic patterns across microbial phylogeny by strain-resolved comparative genomics and comparative metabolomics
Constructed gnotobiotic mouse models to toggle aging-relevant metabolites via manipulating microbes in the gut

*contributed equally

Gut-microbiota-targeted diets modulate human immune status, Cell (2021)

Wastyk HC, Fragiadakis GK, Perelman D, Dahan D, Merrill BD, Yu FB, Topf M, Gonzalez CG, Van Treuren W, Han S, Robinson JL, Elias JE, Sonnenburg ED, Gardner CD, Sonnenburg JL

Longitudinal multi-omics reveals subset-specific mechanisms underlying irritable bowel syndrome, Cell (2020)

Mars RAT, Yang Y, Ward Y, Houtti M, Priya S, Lekatz HR, Tang X, Sun Z, Krishna RK, Korem T, Bhattarai Y, Zheng T, Bar N, Frost G, Johnson AJ, Van Treuren W, Han S, Ordog T, Grover M, Sonnenburg J, D’Amato M, Camilleri M, Elinav E, Segal E, Blekhman R, Farrugia G, Swann JR, Knights D, Kashyap PC

Mono-unsaturated fatty acids link H3K4me3 modifiers to C. elegans lifespan, Nature (2017)

Han S, Schroeder EA, Silva-García CG, Hebestreit K, Mair WB, Brunet A

Discovered a novel role of bioactive lipids (mono-unsaturated fatty acids), which link H3K4me3 chromatin modifiers to lifespan extension in C. elegans
Described the molecular details responsible for the synthesis of these lipids in the intestine and for the germline-to-intestine communication
Demonstrated that dietary intake of mono-unsaturated lipids extends lifespan in the physiological context, highlighting their health benefits could be extended to mammals

p19(Arf) is required for the cellular response to chronic DNA damage, Oncogene (2016)

Bieging-Rolett KT, Johnson TM, Brady CA, Beaudry VG, Pathak N, Han S, Attardi LD

Lysosomal lipid lengthens life span, Science (2015) News and Views

Han S, Brunet A

Histone methylation makes its mark on longevity, Trends Cell Biol (2012) Review

Han S, Brunet A

Members of the H3K4 trimethylation complex regulate lifespan in a germline-dependent manner in C. elegans, Nature (2010)

Greer EL, Maures TJ, Hauswirth AG, Green EM, Leeman DS, Maro GS, Han S, Banko MR, Gozani O, Brunet A