Impact of 7-day homogenous diet on interpersonal variation in human gut microbiomes and metabolomes, Cell Host Microbe (2022)
Guthrie L, Spencer SP, Perelman D, Van Treuren W, Han S, Yu FB, Sonnenburg ED, Fischbach MA, Meyer TW, Sonnenburg JL
A metabolomics pipeline for the mechanistic interrogation of the gut microbiome, Nature (2021)
Han S*, Van Treuren W*, Fischer CR, Merrill BD, DeFelice BC, Sanchez JM, Higginbottom SK, Guthrie L, Fall LA, Dodd D, Fischbach MA, Sonnenburg JL
  • Constructed a microbiome-focused mass-spectrometry reference library and analytical pipeline (Python) to identify 800+ metabolites in diverse sample types
  • Discovered novel metabolic patterns across microbial phylogeny by strain-resolved comparative genomics and comparative metabolomics
  • Constructed gnotobiotic mouse models to toggle aging-relevant metabolites via manipulating microbes in the gut
*contributed equally
Gut-microbiota-targeted diets modulate human immune status, Cell (2021)
Wastyk HC, Fragiadakis GK, Perelman D, Dahan D, Merrill BD, Yu FB, Topf M, Gonzalez CG, Van Treuren W, Han S, Robinson JL, Elias JE, Sonnenburg ED, Gardner CD, Sonnenburg JL
Longitudinal multi-omics reveals subset-specific mechanisms underlying irritable bowel syndrome, Cell (2020)
Mars RAT, Yang Y, Ward Y, Houtti M, Priya S, Lekatz HR, Tang X, Sun Z, Krishna RK, Korem T, Bhattarai Y, Zheng T, Bar N, Frost G, Johnson AJ, Van Treuren W, Han S, Ordog T, Grover M, Sonnenburg J, D’Amato M, Camilleri M, Elinav E, Segal E, Blekhman R, Farrugia G, Swann JR, Knights D, Kashyap PC
Mono-unsaturated fatty acids link H3K4me3 modifiers to C. elegans lifespan, Nature (2017)
Han S, Schroeder EA, Silva-García CG, Hebestreit K, Mair WB, Brunet A
  • Discovered a novel role of bioactive lipids (mono-unsaturated fatty acids), which link H3K4me3 chromatin modifiers to lifespan extension in C. elegans
  • Described the molecular details responsible for the synthesis of these lipids in the intestine and for the germline-to-intestine communication
  • Demonstrated that dietary intake of mono-unsaturated lipids extends lifespan in the physiological context, highlighting their health benefits could be extended to mammals
p19(Arf) is required for the cellular response to chronic DNA damage, Oncogene (2016)
Bieging-Rolett KT, Johnson TM, Brady CA, Beaudry VG, Pathak N, Han S, Attardi LD
Members of the H3K4 trimethylation complex regulate lifespan in a germline-dependent manner in C. elegans, Nature (2010)
Greer EL, Maures TJ, Hauswirth AG, Green EM, Leeman DS, Maro GS, Han S, Banko MR, Gozani O, Brunet A
Duke Biochemistry